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Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes

Deubiquitinating enzymes (DUBs) function to remove or cleave ubiquitin from post-translationally modified protein substrates. There are about 100 known DUBs in the proteome, and their dysregulation has been implicated a number of disease states, but the specific function of many subclass members rem...

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Detalles Bibliográficos
Autores principales: Conole, Daniel, Mondal, Milon, Majmudar, Jaimeen D., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930156/
https://www.ncbi.nlm.nih.gov/pubmed/31921788
http://dx.doi.org/10.3389/fchem.2019.00876