Episomal vectors based on S/MAR and the β-globin Replicator, encoding a synthetic transcriptional activator, mediate efficient γ-globin activation in haematopoietic cells

We report the development of episomal vectors for the specific γ-globin transcription activation in its native position by activator Zif-VP64, based on the Scaffold/Matrix Attachment Region (S/MAR) for episomal retention and the β-globin Replicator, the DNA replication-Initiation Region from the β-g...

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Detalles Bibliográficos
Autores principales: Stavrou, Eleana F., Simantirakis, Emannuouil, Verras, Meletios, Barbas, Carlos, Vassilopoulos, George, Peterson, Kenneth R., Athanassiadou, Aglaia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930265/
https://www.ncbi.nlm.nih.gov/pubmed/31874995
http://dx.doi.org/10.1038/s41598-019-56056-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930265/
https://www.ncbi.nlm.nih.gov/pubmed/31874995
http://dx.doi.org/10.1038/s41598-019-56056-z

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