Targeting MAP3K19 prevents human lung myofibroblast activation both in vitro and in a humanized SCID model of idiopathic pulmonary fibrosis

Idiopathic Pulmonary Fibrosis (IPF) is a disease with a devastating prognosis characterized by unrelenting lung scarring. Aberrant activation of lung fibroblasts is a key feature of this disease, yet the key pathways responsible for this are poorly understood. Mitogen-activated protein kinase, kinas...

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Detalles Bibliográficos
Autores principales: Jones, Isabelle C., Espindola, Milena S., Narayanan, Rohan, Coelho, Ana L., Habiel, David M., Boehme, Stefen A., Ly, Tai Wei, Bacon, Kevin B., Hogaboam, Cory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930295/
https://www.ncbi.nlm.nih.gov/pubmed/31875033
http://dx.doi.org/10.1038/s41598-019-56393-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930295/
https://www.ncbi.nlm.nih.gov/pubmed/31875033
http://dx.doi.org/10.1038/s41598-019-56393-z

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