Lipophilicity Determination of Antifungal Isoxazolo[3,4-b]pyridin-3(1H)-ones and Their N1-Substituted Derivatives with Chromatographic and Computational Methods

The lipophilicity of a molecule is a well-recognized as a crucial physicochemical factor that conditions the biological activity of a drug candidate. This study was aimed to evaluate the lipophilicity of isoxazolo[3,4-b]pyridine-3(1H)-ones and their N1-substituted derivatives, which demonstrated pro...

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Detalles Bibliográficos
Autores principales: Ciura, Krzesimir, Fedorowicz, Joanna, Andrić, Filip, Žuvela, Petar, Greber, Katarzyna Ewa, Baranowski, Paweł, Kawczak, Piotr, Nowakowska, Joanna, Bączek, Tomasz, Sączewski, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930598/
https://www.ncbi.nlm.nih.gov/pubmed/31779124
http://dx.doi.org/10.3390/molecules24234311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930598/
https://www.ncbi.nlm.nih.gov/pubmed/31779124
http://dx.doi.org/10.3390/molecules24234311

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