Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-Phase Arrest on Glioma Cell Lines

The identification of signaling pathways that are involved in gliomagenesis is crucial for targeted therapy design. In this study we assessed the biological and therapeutic effect of ingenol-3-dodecanoate (IngC) on glioma. IngC exhibited dose-time-dependent cytotoxic effects on large panel of glioma...

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Detalles Bibliográficos
Autores principales: Silva, Viviane Aline Oliveira, Rosa, Marcela Nunes, Tansini, Aline, Martinho, Olga, Tanuri, Amilcar, Evangelista, Adriane Feijó, Cruvinel Carloni, Adriana, Lima, João Paulo, Pianowski, Luiz Francisco, Reis, Rui Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930609/
https://www.ncbi.nlm.nih.gov/pubmed/31771098
http://dx.doi.org/10.3390/molecules24234265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930609/
https://www.ncbi.nlm.nih.gov/pubmed/31771098
http://dx.doi.org/10.3390/molecules24234265

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