Construction of Quantitative Structure Activity Relationship (QSAR) Models to Predict Potency of Structurally Diversed Janus Kinase 2 Inhibitors

Janus kinase 2 (JAK2) inhibitors represent a promising therapeutic class of anticancer agents against many myeloproliferative disorders. Bioactivity data on pIC [Formula: see text] of 2229 JAK2 inhibitors were employed in the construction of quantitative structure-activity relationship (QSAR) models...

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Detalles Bibliográficos
Autores principales: Simeon, Saw, Jongkon, Nathjanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930640/
https://www.ncbi.nlm.nih.gov/pubmed/31805692
http://dx.doi.org/10.3390/molecules24234393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930640/
https://www.ncbi.nlm.nih.gov/pubmed/31805692
http://dx.doi.org/10.3390/molecules24234393

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