Copper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove

Herein, we report the synthesis, characterisation, X-ray crystallography, and oxidative DNA binding interactions of the copper artificial metallo-nuclease [Cu(DPQ)(2)(NO(3))](NO(3)), where DPQ = dipyrido[3,2-f:2′,3′-h]quinoxaline. The cation [Cu(DPQ)(2)](2+) (Cu-DPQ), is a high-affinity binder of du...

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Detalles Bibliográficos
Autores principales: Molphy, Zara, McKee, Vickie, Kellett, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930674/
https://www.ncbi.nlm.nih.gov/pubmed/31779066
http://dx.doi.org/10.3390/molecules24234301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930674/
https://www.ncbi.nlm.nih.gov/pubmed/31779066
http://dx.doi.org/10.3390/molecules24234301

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