Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening

Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients’ immune systems, leading to poor disease outcomes. Both enzymes are validated targets for cancer immu...

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Detalles Bibliográficos
Autores principales: Sari, Suat, Tomek, Petr, Leung, Euphemia, Reynisson, Jóhannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930675/
https://www.ncbi.nlm.nih.gov/pubmed/31795096
http://dx.doi.org/10.3390/molecules24234346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930675/
https://www.ncbi.nlm.nih.gov/pubmed/31795096
http://dx.doi.org/10.3390/molecules24234346

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