Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

Bayesian forecasting for dose individualization of prophylactic factor VIII replacement therapy using pharmacokinetic samples is challenged by large interindividual variability in the bleeding risk. A pharmacokinetic‐repeated time‐to‐event model‐based forecasting approach was developed to contrast t...

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Detalles Bibliográficos
Autores principales: Abrantes, João A., Solms, Alexander, Garmann, Dirk, Nielsen, Elisabet I., Jönsson, Siv, Karlsson, Mats O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930854/
https://www.ncbi.nlm.nih.gov/pubmed/31668021
http://dx.doi.org/10.1002/psp4.12464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930854/
https://www.ncbi.nlm.nih.gov/pubmed/31668021
http://dx.doi.org/10.1002/psp4.12464

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