Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells

IL12 is an immune-stimulatory cytokine for key immune cells including T cells and NK cells. However, systemic administration of IL12 has serious side effects that limit its clinical application in patients. Recently, synthetic Notch (synNotch) receptors have been developed that induce transcriptiona...

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Detalles Bibliográficos
Autores principales: Luo, Hong, Wu, Xiuqi, Sun, Ruixin, Su, Jingwen, Wang, Yi, Dong, Yiwei, Shi, Bizhi, Sun, Yansha, Jiang, Hua, Li, Zonghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930917/
https://www.ncbi.nlm.nih.gov/pubmed/31921693
http://dx.doi.org/10.3389/fonc.2019.01448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930917/
https://www.ncbi.nlm.nih.gov/pubmed/31921693
http://dx.doi.org/10.3389/fonc.2019.01448

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