Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates

Meningococcal lipoprotein, Factor H binding protein (FHbp), is the sole antigen of the Trumenba vaccine (Pfizer) and one of four antigens of the Bexsero vaccine (GSK) targeting Neisseria meningitidis serogroup B isolates. Lipidation of FHbp is assumed to occur for all isolates. We show in the majori...

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Detalles Bibliográficos
Autores principales: da Silva, Ronni A. G., Karlyshev, Andrey V., Oldfield, Neil J., Wooldridge, Karl G., Bayliss, Christopher D., Ryan, Ali, Griffin, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930937/
https://www.ncbi.nlm.nih.gov/pubmed/31921030
http://dx.doi.org/10.3389/fmicb.2019.02847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930937/
https://www.ncbi.nlm.nih.gov/pubmed/31921030
http://dx.doi.org/10.3389/fmicb.2019.02847

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