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A novel method for efficient generation of antigen-specific effector T-cells using dendritic cells transduced with recombinant adeno-associated virus and p38 kinase blockade

BACKGROUND: The inefficacy of standard therapeutic strategies for ovarian cancer is reflected by the enduring poor prognosis of this malignancy. Due to the potential for exquisite specificity, sensitivity and long-term memory, immunotherapy offers an alternative modality for durable control of the d...

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Detalles Bibliográficos
Autores principales: Mirandola, Leonardo, Chiriva-Internati, Maurizio, Bresalier, Robert, Piccotti, Lucia, Grizzi, Fabio, Marincola, Francesco M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931250/
https://www.ncbi.nlm.nih.gov/pubmed/31878933
http://dx.doi.org/10.1186/s12967-019-02163-4