Cargando…

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a rol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takahashi, Shun-saku, Sou, Yu-Shin, Saito, Tetsuya, Kuma, Akiko, Yabe, Takayuki, Sugiura, Yuki, Lee, Hyeon-Cheol, Suematsu, Makoto, Yokomizo, Takehiko, Koike, Masato, Terai, Shuji, Mizushima, Noboru, Waguri, Satoshi, Komatsu, Masaaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932742/ https://www.ncbi.nlm.nih.gov/pubmed/31879337 http://dx.doi.org/10.26508/lsa.201900513

Ejemplares similares

Autophagy regulates lipid metabolism through selective turnover of NCoR1
por: Saito, Tetsuya, et al.
Publicado: (2019)

Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals
por: Privalsky, Martin L., et al.
Publicado: (2019)

Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases
por: Paluvai, Harikrishnareddy, et al.
Publicado: (2023)

NCoR controls glioblastoma tumor cell characteristics
por: Heldring, Nina, et al.
Publicado: (2014)

CK2-NCoR signaling cascade promotes prostate tumorigenesis
por: Yoo, Jung-Yoon, et al.
Publicado: (2013)

NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance
por: Ahad, Abdul, et al.
Publicado: (2019)

Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer
por: Beilner, Daniel, et al.
Publicado: (2021)

Autophagy-monitoring and autophagy-deficient mice
por: Kuma, Akiko, et al.
Publicado: (2017)

Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
por: Korman, Benjamin, et al.
Publicado: (2018)

Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance
por: Gallardo, Fernando, et al.
Publicado: (2015)

The Role of Nuclear Receptor Corepressors NCoR1 and SMRT on Physiologic Function in the Adult Mouse
por: Ritter, Megan J, et al.
Publicado: (2021)

Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ
por: Mosure, Sarah A., et al.
Publicado: (2021)

The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate
por: Lackner, Andreas, et al.
Publicado: (2023)

Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex
por: Hudson, Gregg M., et al.
Publicado: (2015)

Nuclear Receptor Corepressors NCoR1 and SMRT Plays Unique Roles in Central Nervous System
por: Amano, Izuki, et al.
Publicado: (2021)

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression
por: Yu, Lei, et al.
Publicado: (2018)

Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
por: Matsumura, Yoshihiro, et al.
Publicado: (2021)

MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex
por: Kyle, Stephanie M., et al.
Publicado: (2016)

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
por: Wang, Jianrong, et al.
Publicado: (2017)

COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR
por: Lu, Renquan, et al.
Publicado: (2016)

NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation
por: Sen, Kaushik, et al.
Publicado: (2022)

NCoR1 controls Mycobacterium tuberculosis growth in myeloid cells by regulating the AMPK-mTOR-TFEB axis
por: Biswas, Viplov Kumar, et al.
Publicado: (2023)

p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1
por: Shi, Min Yan, et al.
Publicado: (2023)

Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1
por: Choi, You-Jin, et al.
Publicado: (2023)

Short linear motif acquisition, exon formation and alternative splicing determine a pathway to diversity for NCoR-family co-repressors
por: Short, Stephen, et al.
Publicado: (2015)

Specific ablation of the NCoR corepressor δ splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism
por: Goodson, Michael L., et al.
Publicado: (2020)

HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity
por: Szigety, Katherine M., et al.
Publicado: (2020)

SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling
por: Jha, Atimukta, et al.
Publicado: (2022)

Author Correction: p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1
por: Shi, Min Yan, et al.
Publicado: (2023)

GEI-8, a Homologue of Vertebrate Nuclear Receptor Corepressor NCoR/SMRT, Regulates Gonad Development and Neuronal Functions in Caenorhabditis elegans
por: Mikoláš, Pavol, et al.
Publicado: (2013)

A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes
por: Oswald, Franz, et al.
Publicado: (2016)

Autophagic Degradation of Misfolded Nuclear Receptor Co-repressor (NCoR) Is Linked to the Growth of Tumor Cells in HBX Positive Hepatocellular Carcinoma (HCC)
por: Tan, Su Yin, et al.
Publicado: (2019)

NCoR1 Protects Mice From Dextran Sodium Sulfate–Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult
por: Mennillo, Elvira, et al.
Publicado: (2020)

SUMOylation of PPARγ by Rosiglitazone Prevents LPS-Induced NCoR Degradation Mediating Down Regulation of Chemokines Expression in Renal Proximal Tubular Cells
por: Lu, Ying, et al.
Publicado: (2013)

The pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma
por: Rigalli, Juan Pablo, et al.
Publicado: (2018)

Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis
por: Chen, Zhe, et al.
Publicado: (2021)

Interaction between poly(A)–binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response
por: Oliveira, A.G., et al.
Publicado: (2023)

miR-221 Alleviates the Ox-LDL-Induced Macrophage Inflammatory Response via the Inhibition of DNMT3b-Mediated NCoR Promoter Methylation
por: Ye, Jinshan, et al.
Publicado: (2019)

Corrigendum to “miR-221 Alleviates the Ox-LDL-Induced Macrophage Inflammatory Response via the Inhibition of DNMT3b-Mediated NCoR Promoter Methylation”
por: Ye, Jinshan, et al.
Publicado: (2020)

Epigenomics of conventional type-I dendritic cells depicted preferential control of TLR9 versus TLR3 response by NCoR1 through differential IRF3 activation
por: Mishra, Gyan Prakash, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m4i3ek9t1p4miudep8fr39sc3c