α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway

The production of reactive oxygen species (ROS) by cisplatin is one of the major mechanisms of cisplatin-induced cytotoxicity. We examined the preventive effect of α-lipoic acid (LA) on cisplatin-induced toxicity via its antioxidant effects on in vitro and ex vivo culture systems. To elucidate the m...

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Detalles Bibliográficos
Autores principales: Lee, Joohyung, Jung, So-Young, Yang, Keum-Jin, Kim, Yoonho, Lee, Dohee, Lee, Min Hyeong, Kim, Dong-Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932784/
https://www.ncbi.nlm.nih.gov/pubmed/31877176
http://dx.doi.org/10.1371/journal.pone.0226769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932784/
https://www.ncbi.nlm.nih.gov/pubmed/31877176
http://dx.doi.org/10.1371/journal.pone.0226769

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