HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway

Non-alcoholic fatty liver disease (NAFLD) is a relevant risk factor for developing hepatocellular carcinoma (HCC). Steatohepatitic HCC (SH-HCC), characterized by HCC with steatosis, is influenced by lipid metabolism disorders. A hypoxic microenvironment is common in HCC and affects lipid metabolism....

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Detalles Bibliográficos
Autores principales: Chen, Jianxu, Chen, Jiandi, Huang, Jiaxin, Li, Zhanyu, Gong, Yihang, Zou, Baojia, Liu, Xialei, Ding, Lei, Li, Peiping, Zhu, Zhiquan, Zhang, Baimeng, Guo, Hui, Cai, Chaonong, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932893/
https://www.ncbi.nlm.nih.gov/pubmed/31796646
http://dx.doi.org/10.18632/aging.102488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932893/
https://www.ncbi.nlm.nih.gov/pubmed/31796646
http://dx.doi.org/10.18632/aging.102488

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