Cargando…

Genomic landscapes by multiregion sequencing combined with circulation tumor DNA detection contribute to molecular diagnosis in glioblastomas

Glioblastoma is a highly aggressive brain malignancy with a poor prognosis. Its high intratumor heterogeneity contributes to therapeutic resistance, tumor progression and recurrence. We sequenced 31 loci in 11 patients with glioblastoma (including one patient with samples available from the primary...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Chao, Tan, Yanli, Li, Shouwei, Zhou, Junhu, Wang, Qixue, Wang, Yunfei, Xie, Yingbin, Chen, Luyue, Li, Jie, Fang, Chuan, Kang, Chunsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932900/ https://www.ncbi.nlm.nih.gov/pubmed/31822636 http://dx.doi.org/10.18632/aging.102526

Ejemplares similares

TGFβ signaling-induced miRNA participates in autophagic regulation by targeting PRAS40 in mesenchymal subtype of glioblastoma
por: Xie, Yingbin, et al.
Publicado: (2020)

Expert opinion on translational research for advanced glioblastoma treatment
por: Cui, Xiaoteng, et al.
Publicado: (2023)

RUNX1 contributes to the mesenchymal subtype of glioblastoma in a TGFβ pathway-dependent manner
por: Zhao, Kai, et al.
Publicado: (2019)

Single-cell RNA-seq reveals RAD51AP1 as a potent mediator of EGFRvIII in human glioblastomas
por: Wang, Qixue, et al.
Publicado: (2019)

Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway
por: Wang, Qixue, et al.
Publicado: (2018)

Homotrimer cavin1 interacts with caveolin1 to facilitate tumor growth and activate microglia through extracellular vesicles in glioma
por: Wang, Lin, et al.
Publicado: (2020)

Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma
por: Huang, Kai, et al.
Publicado: (2019)

Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019)
por: Huang, Kai, et al.
Publicado: (2019)

Single-Cell Transcriptomics of Glioblastoma Reveals a Unique Tumor Microenvironment and Potential Immunotherapeutic Target Against Tumor-Associated Macrophage
por: Cui, Xiaoteng, et al.
Publicado: (2021)

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma
por: Cui, Xiaoteng, et al.
Publicado: (2023)

Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein
por: Wang, Lin, et al.
Publicado: (2021)

Neuronal STAT3/HIF-1α/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A
por: Jin, Weili, et al.
Publicado: (2022)

PTRF/Cavin-1 as a Novel RNA-Binding Protein Expedites the NF-κB/PD-L1 Axis by Stabilizing lncRNA NEAT1, Contributing to Tumorigenesis and Immune Evasion in Glioblastoma
por: Yi, Kaikai, et al.
Publicado: (2022)

Sensor-Oriented Path Planning for Multiregion Surveillance with a Single Lightweight UAV SAR
por: Li, Jincheng, et al.
Publicado: (2018)

LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses UBXN1 expression and activates NF-κB activity, promoting tumorigenesis
por: Li, Yansheng, et al.
Publicado: (2021)

miRNA interventions serve as ‘magic bullets’ in the reversal of glioblastoma hallmarks
por: Chen, Luyue, et al.
Publicado: (2015)

Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
por: Wang, Qixue, et al.
Publicado: (2019)

The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells
por: Wang, Qixue, et al.
Publicado: (2019)

Editorial: The State-of-Art in Immuno-Oncology, What to Do With Glioblastoma?
por: Cui, Xiaoteng, et al.
Publicado: (2021)

PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma
por: Yang, Eryan, et al.
Publicado: (2022)

HOTAIR is a therapeutic target in glioblastoma
por: Zhou, Xuan, et al.
Publicado: (2015)

TCA-phospholipid-glycolysis targeted triple therapy effectively suppresses ATP production and tumor growth in glioblastoma
por: Yang, Shixue, et al.
Publicado: (2022)

SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma
por: Chen, Luyue, et al.
Publicado: (2015)

A Compound AC1Q3QWB Selectively Disrupts HOTAIR-Mediated Recruitment of PRC2 and Enhances Cancer Therapy of DZNep
por: Li, Yansheng, et al.
Publicado: (2019)

Multiregion single‐cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancer
por: Wang, Wei, et al.
Publicado: (2021)

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression
por: Zhao, Hongyu, et al.
Publicado: (2020)

Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance
por: Zhou, Junhu, et al.
Publicado: (2023)

Multiregional Tumor Trees Are Not Phylogenies
por: Alves, João M., et al.
Publicado: (2017)

Machine Learning Based on a Multiparametric and Multiregional Radiomics Signature Predicts Radiotherapeutic Response in Patients with Glioblastoma
por: Pan, Zi-Qi, et al.
Publicado: (2020)

Multiregional radiomic model for breast cancer diagnosis: value of ultrasound-based peritumoral and parenchymal radiomics
por: Guo, Suping, et al.
Publicado: (2023)

HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways
por: Duan, Ran, et al.
Publicado: (2015)

Boosting of the enhanced permeability and retention effect with nanocapsules improves the therapeutic effects of cetuximab
por: Yang, Chao, et al.
Publicado: (2020)

HOTAIR Up-Regulation Activates NF-κB to Induce Immunoescape in Gliomas
por: Wang, Yunfei, et al.
Publicado: (2021)

Effects of combined radiosurgery and temozolomide therapy on epidermal growth factor receptor and variant III in glioblastoma multiforme
por: Lin, Yiguang, et al.
Publicado: (2018)

Multiregional origins of the domesticated tetraploid wheats
por: Oliveira, Hugo R., et al.
Publicado: (2020)

Multiregion neuronal activity: the forest and the trees
por: Machado, Timothy A., et al.
Publicado: (2022)

Multiregional radiomics profiling from multiparametric MRI: Identifying an imaging predictor of IDH1 mutation status in glioblastoma
por: Li, Zhi‐Cheng, et al.
Publicado: (2018)

Omics-based integrated analysis identified ATRX as a biomarker associated with glioma diagnosis and prognosis
por: Xie, Yingbin, et al.
Publicado: (2019)

Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner
por: Zhang, Kailiang, et al.
Publicado: (2014)

Multiregional Sequencing of IDH-WT Glioblastoma Reveals High Genetic Heterogeneity and a Dynamic Evolutionary History
por: Franceschi, Sara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rusf3dkijf3o5gsnl56stsa293