Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model

The implication of epigenetic mechanisms in Alzheimer’s disease (AD) has been demonstrated in several studies. UNC0642, a specific and potent inhibitor of methyltransferase activity G9a/GLP (G9a-like) complex, was evaluated in the 5XFAD mouse model. UNC0642 treatment rescued 5XFAD cognition impairme...

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Detalles Bibliográficos
Autores principales: Griñán-Ferré, Christian, Marsal-García, Laura, Bellver-Sanchis, Aina, Kondengaden, Shukkoor Muhammed, Turga, Ravi Chakra, Vázquez, Santiago, Pallàs, Mercè
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932909/
https://www.ncbi.nlm.nih.gov/pubmed/31804189
http://dx.doi.org/10.18632/aging.102558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932909/
https://www.ncbi.nlm.nih.gov/pubmed/31804189
http://dx.doi.org/10.18632/aging.102558

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