Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and –independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin

Background: There are 200-600 million betel quid (BQ) chewers in the world. BQ increases oral cancer risk. Matrix metalloproteinase-9 (MMP-9) is responsible for matrix degradation, cancer invasion and metastasis. Whether areca nut extract (ANE), a BQ component, stimulates MMP-9 secretion, and the re...

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Detalles Bibliográficos
Autores principales: Chang, Mei-Chi, Pan, Yu-Hwa, Wu, Hsyueh-Liang, Lu, Yi-Jie, Liao, Wan-Chuen, Yeh, Chien-Yang, Lee, Jang-Jaer, Jeng, Jiiang-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932916/
https://www.ncbi.nlm.nih.gov/pubmed/31831717
http://dx.doi.org/10.18632/aging.102565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932916/
https://www.ncbi.nlm.nih.gov/pubmed/31831717
http://dx.doi.org/10.18632/aging.102565

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