Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer

Alterations in KEAP1/ NF-E2 p45-related factor 2 (NFE2L2/Nrf2) signaling pathway have been reported in 23% lung adenocarcinoma patients, suggesting that deregulation of the pathway is a major cancer driver. Here we report that mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) drives tumor...

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Detalles Bibliográficos
Autores principales: Wang, Hongyan, Liu, Kaihua, Chi, Zhexu, Zhou, Xihang, Ren, Guoping, Zhou, Ren, Li, Yinyan, Tang, Xiuwen, Wang, Xiu Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932920/
https://www.ncbi.nlm.nih.gov/pubmed/31811110
http://dx.doi.org/10.18632/aging.102531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932920/
https://www.ncbi.nlm.nih.gov/pubmed/31811110
http://dx.doi.org/10.18632/aging.102531

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