Cargando…

Melatonin protects blood-brain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3/NF-κB pathway

The pathophysiological mechanism of white matter hyperintensities of cerebral small vessel disease (CSVD) includes an impaired blood-brain barrier (BBB) with increased permeability. Neuroinflammation likely contributes to the disruption of the BBB in CSVD. Therefore, understanding the molecular mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Weiwei, Li, Jing, Zhu, Rongjia, Gao, Suhua, Fan, Junfen, Xia, Mingrong, Zhao, Robert Chunhua, Zhang, Jiewen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932927/ https://www.ncbi.nlm.nih.gov/pubmed/31811815 http://dx.doi.org/10.18632/aging.102537

Ejemplares similares

Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition
por: Alluri, Himakarnika, et al.
Publicado: (2016)

Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-κB activation
por: Al-Sadi, Rana, et al.
Publicado: (2021)

Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro
por: Apostolidou, Eleni, et al.
Publicado: (2012)

Rhubarb Antagonizes Matrix Metalloproteinase-9-induced Vascular Endothelial Permeability
por: Cui, Yun-Liang, et al.
Publicado: (2016)

Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis
por: Mailankody, Sharada, et al.
Publicado: (2017)

Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins
por: Feng, Saran, et al.
Publicado: (2011)

Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells
por: Lee, Yueh-Lun, et al.
Publicado: (2018)

Correction: Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins
por: Feng, Saran, et al.
Publicado: (2011)

Matrix metalloproteinase-2 and −9 contribute to functional integrity and noise-induced damage to the blood-labyrinth-barrier
por: Wu, Jun, et al.
Publicado: (2017)

Allele-Specific Regulation of Matrix Metalloproteinase-3 Gene by Transcription Factor NFκB
por: Souslova, Veronika, et al.
Publicado: (2010)

Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis
por: Li, Yusheng, et al.
Publicado: (2016)

Clusterin Silencing in Prostate Cancer Induces Matrix Metalloproteinases by an NF-κB-Dependent Mechanism
por: Bonacini, Martina, et al.
Publicado: (2019)

Interleukin 17A Promotes Gastric Cancer Invasiveness via NF-κB Mediated Matrix Metalloproteinases 2 and 9 Expression
por: Wang, Yidong, et al.
Publicado: (2014)

A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-κB
por: Freise, Christian, et al.
Publicado: (2015)

Enhanced Vascular Permeability in Solid Tumor Involving Peroxynitrite and Matrix Metalloproteinases
por: Wu, Jun, et al.
Publicado: (2001)

Matrix metalloproteinase 9-dependent Notch signaling contributes to kidney fibrosis through peritubular endothelial–mesenchymal transition
por: Zhao, Ye, et al.
Publicado: (2017)

Delta/Notch signaling in glia maintains motor nerve barrier function and synaptic transmission by controlling matrix metalloproteinase expression
por: Calderon, Mario R., et al.
Publicado: (2022)

Overexpression of Integrin-linked Kinase Promotes Lung Cancer Cell Migration and Invasion via NF-κB-mediated Upregulation of Matrix Metalloproteinase-9
por: Zhao, Mingjing, et al.
Publicado: (2013)

Lysophosphatidic Acid Is Associated with Atherosclerotic Plaque Instability by Regulating NF-κB Dependent Matrix Metalloproteinase-9 Expression via LPA(2) in Macrophages
por: Gu, Chun, et al.
Publicado: (2017)

Triptolide inhibits matrix metalloproteinase-9 expression and invasion of breast cancer cells through the inhibition of NF-κB and AP-1 signaling pathways
por: Hong, On-Yu, et al.
Publicado: (2021)

Clinical Features of 4 Novel NOTCH3 Mutations of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy in China
por: Qin, Weiwei, et al.
Publicado: (2019)

Low level laser (LLL) attenuate LPS-induced inflammatory responses in mesenchymal stem cells via the suppression of NF-κB signaling pathway in vitro
por: Yin, Kan, et al.
Publicado: (2017)

Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells
por: Zhao, Ye, et al.
Publicado: (2016)

Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer
por: Tanioka, Y, et al.
Publicado: (2003)

Interleukin-33, matrix metalloproteinase-9, and tissue ınhibitor of matrix metalloproteinase-1 in myocardial infarction
por: Guzel, Savas, et al.
Publicado: (2013)

Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients
por: Trentini, Alessandro, et al.
Publicado: (2016)

Matrix Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Aqueous Humor of Diabetic Macular Edema Patients
por: Kwon, Jin-woo, et al.
Publicado: (2016)

Intracranial High-Grade Stenosis and Hyperhomocysteinemia Presenting as Cortical Subarachnoid Hemorrhage Concomitant with Acute Ischemic Stroke in a Young Man
por: Qin, Weiwei, et al.
Publicado: (2020)

Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice
por: Oppenheim, Hannah A, et al.
Publicado: (2013)

∆9-tetrahydrocannabinol inhibits epithelial-mesenchymal transition and metastasis by targeting matrix metalloproteinase-9 in endometrial cancer
por: Zhang, Yingzhi, et al.
Publicado: (2018)

Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation
por: Yeh, Chia-Ming, et al.
Publicado: (2016)

Matrix Metalloproteinase-9 Leads to Claudin-5 Degradation via the NF-κB Pathway in BALB/c Mice with Eosinophilic Meningoencephalitis Caused by Angiostrongylus cantonensis
por: Chiu, Ping-Sung, et al.
Publicado: (2013)

Terminalia catappa Exerts Antimetastatic Effects on Hepatocellular Carcinoma through Transcriptional Inhibition of Matrix Metalloproteinase-9 by Modulating NF-κB and AP-1 Activity
por: Yeh, Chao-Bin, et al.
Publicado: (2012)

Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression
por: Guo, Yong, et al.
Publicado: (2019)

Avenanthramide C Suppresses Matrix Metalloproteinase-9 Expression and Migration Through the MAPK/NF- κB Signaling Pathway in TNF-α-Activated HASMC Cells
por: Park, Junyoung, et al.
Publicado: (2021)

Important role of matrix metalloproteinase 9 in epileptogenesis
por: Wilczynski, Grzegorz M., et al.
Publicado: (2008)

Expression of Matrix Metalloproteinase-9 in Gastric Cancer
por: R, Prathipaa, et al.
Publicado: (2021)

Correlation between expression of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) and angiogenesis in colorectal adenocarcinoma.
por: Kim, T. S., et al.
Publicado: (1999)

Erratum: Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinase-1 in myocardial infarction
por: Guzel, Savas, et al.
Publicado: (2013)

Elevated Expression of Matrix Metalloproteinase-9 not Matrix Metalloproteinase-2 Contributes to Progression of Extracranial Arteriovenous Malformation
por: Wei, Ting, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4bh3e6cittbo0q05scesi4omlu