Modulation of μ‐opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue

BACKGROUND AND PURPOSE: Adverse side effects of conventional opioids can be avoided if ligands selectively activate peripheral opioid receptors in injured tissue. Injury and inflammation are typically accompanied by acidification. In this study, we examined influences of low pH and mutation of the i...

Descripción completa

Detalles Bibliográficos
Autores principales: Meyer, Johanna, Del Vecchio, Giovanna, Seitz, Viola, Massaly, Nicolas, Stein, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932940/
https://www.ncbi.nlm.nih.gov/pubmed/31355457
http://dx.doi.org/10.1111/bph.14810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932940/
https://www.ncbi.nlm.nih.gov/pubmed/31355457
http://dx.doi.org/10.1111/bph.14810

Ejemplares similares