Inhibition of the hyaluronan matrix enhances metabolic anticancer therapy by dichloroacetate in vitro and in vivo

BACKGROUND AND PURPOSE: Aerobic glycolysis is a unique feature of tumour cells that entails several advantages for cancer progression such as resistance to apoptosis. The low MW compound, dichloroacetate, is a pyruvate dehydrogenase kinase inhibitor, which restores oxidative phosphorylation and indu...

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Detalles Bibliográficos
Autores principales: Twarock, Sören, Reichert, Christina, Bach, Katharina, Reiners, Oliver, Kretschmer, Inga, Gorski, Daniel J., Gorges, Katharina, Grandoch, Maria, Fischer, Jens W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932941/
https://www.ncbi.nlm.nih.gov/pubmed/31351004
http://dx.doi.org/10.1111/bph.14808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932941/
https://www.ncbi.nlm.nih.gov/pubmed/31351004
http://dx.doi.org/10.1111/bph.14808

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