NS5806 Induces Electromechanically Discordant Alternans and Arrhythmogenic Voltage-Calcium Dynamics in the Isolated Intact Rabbit Heart
Background: NS5806 activates the transient outward potassium current I(to), and has been claimed to reproduce Brugada Syndrome (BrS) in ventricular wedge preparations. I(to) modulates excitation-contraction coupling, which is critical in alternans dynamics. We explored NS5806-arrhythmogenic effects...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933003/ https://www.ncbi.nlm.nih.gov/pubmed/31920713 http://dx.doi.org/10.3389/fphys.2019.01509 |