Cargando…

BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

OBJECTIVE: Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. Here, we exam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoffmann, Jenny M., Grünberg, John R., Hammarstedt, Ann, Kroon, Tobias, Greiner, Thomas U., Maurer, Stefanie, Elias, Ivet, Palsdottir, Vilborg, Bosch, Fatima, Boucher, Jeremie, Hedjazifar, Shahram, Smith, Ulf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933264/ https://www.ncbi.nlm.nih.gov/pubmed/32029225 http://dx.doi.org/10.1016/j.molmet.2019.11.016

Ejemplares similares

Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver
por: Khatib Shahidi, Roxana, et al.
Publicado: (2021)

Restricted Adipogenesis in Hypertrophic Obesity: The Role of WISP2, WNT, and BMP4
por: Gustafson, Birgit, et al.
Publicado: (2013)

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance
por: Grünberg, John R., et al.
Publicado: (2017)

CCN5/WISP2 and metabolic diseases
por: Grünberg, John R, et al.
Publicado: (2017)

New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance
por: Elias, Ivet, et al.
Publicado: (2013)

In Vivo Adeno-Associated Viral Vector–Mediated Genetic Engineering of White and Brown Adipose Tissue in Adult Mice
por: Jimenez, Veronica, et al.
Publicado: (2013)

BMP8 and activated brown adipose tissue in human newborns
por: Urisarri, Adela, et al.
Publicado: (2021)

Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813
por: Elias, Ivet, et al.
Publicado: (2013)

PPARγ and PPARα synergize to induce robust browning of white fat in vivo
por: Kroon, Tobias, et al.
Publicado: (2020)

Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity
por: Longo, Michele, et al.
Publicado: (2017)

BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality
por: Boon, Mariëtte R., et al.
Publicado: (2013)

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions
por: Whittle, Andrew J., et al.
Publicado: (2012)

BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis
por: Mu, Wenjuan, et al.
Publicado: (2021)

Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue
por: Dieckmann, Sebastian, et al.
Publicado: (2020)

BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH
por: Baboota, Ritesh K., et al.
Publicado: (2022)

Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat
por: Schulz, Tim J., et al.
Publicado: (2013)

Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning
por: Gómez-García, Iker, et al.
Publicado: (2022)

Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning
por: Patil, Mallikarjun, et al.
Publicado: (2017)

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance
por: Elias, Ivet, et al.
Publicado: (2012)

Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice
por: Laiglesia, Laura M., et al.
Publicado: (2023)

Editorial: Insights Into Brown Adipose Tissue Functions and Browning Phenomenon
por: Oliver, Paula, et al.
Publicado: (2020)

mTORC2 sustains thermogenesis via Akt‐induced glucose uptake and glycolysis in brown adipose tissue
por: Albert, Verena, et al.
Publicado: (2016)

Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells
por: Hammarstedt, Ann, et al.
Publicado: (2012)

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
por: Weiner, Juliane, et al.
Publicado: (2016)

Adipose tissue plasticity and the pleiotropic roles of BMP signaling
por: Qian, Shuwen, et al.
Publicado: (2021)

Increased weight loading reduces body weight and body fat in obese subjects – A proof of concept randomized clinical trial
por: Ohlsson, Claes, et al.
Publicado: (2020)

Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk
por: Kaikaew, Kasiphak, et al.
Publicado: (2021)

Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue
por: Wankhade, Umesh D., et al.
Publicado: (2016)

Brown Adipose Tissue Growth and Development
por: Symonds, Michael E.
Publicado: (2013)

Assessment of brown adipose tissue function
por: Virtue, Sam, et al.
Publicado: (2013)

Brown Adipose Tissue in Cetacean Blubber
por: Hashimoto, Osamu, et al.
Publicado: (2015)

White adipose tissue browning and obesity
por: Cui, Xiao-Bing, et al.
Publicado: (2017)

Exercise-induced ‘browning’ of adipose tissues
por: Aldiss, Peter, et al.
Publicado: (2018)

Dietary Proteins, Brown Fat, and Adiposity
por: Madsen, Lise, et al.
Publicado: (2018)

Brown and Beige Adipose Tissue and Aging
por: Zoico, Elena, et al.
Publicado: (2019)

The Heartwarming Effect of Brown Adipose Tissue
por: Pinckard, Kelsey M., et al.
Publicado: (2022)

Nutraceuticals in Brown Adipose Tissue Activation
por: Armani, Andrea, et al.
Publicado: (2022)

Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children
por: Tint, Mya Thway, et al.
Publicado: (2021)

Regulatory effects and mechanisms of exercise on activation of brown adipose tissue (BAT) and browning of white adipose tissue (WAT)
por: Dong, Haijun, et al.
Publicado: (2023)

Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids
por: Hammarstedt, Ann, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_h66lv08h2dcsje1qhim6bluudd