Knockout of beta‐2 microglobulin reduces stem cell‐induced immune rejection and enhances ischaemic hindlimb repair via exosome/miR‐24/Bim pathway

Generating universal human umbilical mesenchymal stem cells (UMSCs) without immune rejection is desirable for clinical application. Here we developed an innovative strategy using CRISPR/Cas9 to generate B2M(‐)UMSCs in which human leucocyte antigen (HLA) light chain β2‐microglobulin (B2M) was deleted...

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Detalles Bibliográficos
Autores principales: Zhang, Yuqing, Wang, Yanli, Shao, Lianbo, Pan, Xiangbin, Liang, Chun, Liu, Bin, Zhang, Yu, Xie, Wenping, Yan, Bing, Liu, Feng, Yu, Xi‐yong, Li, Yangxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933348/
https://www.ncbi.nlm.nih.gov/pubmed/31729180
http://dx.doi.org/10.1111/jcmm.14778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933348/
https://www.ncbi.nlm.nih.gov/pubmed/31729180
http://dx.doi.org/10.1111/jcmm.14778

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