Cargando…
Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism
Flaviviruses cause systemic or neurotropic-encephalitic pathology in humans. The flavivirus nonstructural protein 1 (NS1) is a secreted glycoprotein involved in viral replication, immune evasion, and vascular leakage during dengue virus infection. However, the contribution of secreted NS1 from relat...
Autores principales: | Puerta-Guardo, Henry, Glasner, Dustin R., Espinosa, Diego A., Biering, Scott B., Patana, Mark, Ratnasiri, Kalani, Wang, Chunling, Beatty, P. Robert, Harris, Eva |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934102/ https://www.ncbi.nlm.nih.gov/pubmed/30726741 http://dx.doi.org/10.1016/j.celrep.2019.01.036 |
Ejemplares similares
-
Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation
por: Wang, Chunling, et al.
Publicado: (2019) -
Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components
por: Glasner, Dustin R., et al.
Publicado: (2017) -
Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner
por: Puerta-Guardo, Henry, et al.
Publicado: (2022) -
Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability
por: Puerta-Guardo, Henry, et al.
Publicado: (2016) -
Broad Host Tropism of Flaviviruses during the Entry Stage
por: Zhang, Yanan, et al.
Publicado: (2023)