Modulation of p53 Transactivation Domain Conformations by Ligand Binding and Cancer-Associated Mutations

Intrinsically disordered proteins (IDPs) are important functional proteins, and their deregulation are linked to numerous human diseases including cancers. Understanding how disease-associated mutations or drug molecules can perturb the sequence-disordered ensemble-function-disease relationship of I...

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Detalles Bibliográficos
Autores principales: Liu, Xiaorong, Chen, Jianhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934143/
https://www.ncbi.nlm.nih.gov/pubmed/31797597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934143/
https://www.ncbi.nlm.nih.gov/pubmed/31797597

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