Cargando…

Molecular structures of the human Slo1 K(+) channel in complex with β4

Slo1 is a Ca(2+)- and voltage-activated K(+) channel that underlies skeletal and smooth muscle contraction, audition, hormone secretion and neurotransmitter release. In mammals, Slo1 is regulated by auxiliary proteins that confer tissue-specific gating and pharmacological properties. This study pres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tao, Xiao, MacKinnon, Roderick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934384/ https://www.ncbi.nlm.nih.gov/pubmed/31815672 http://dx.doi.org/10.7554/eLife.51409

Ejemplares similares

Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology
por: Tao, Xiao, et al.
Publicado: (2019)

Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel
por: Banerjee, Anirban, et al.
Publicado: (2013)

Structure of the CLC-1 chloride channel from Homo sapiens
por: Park, Eunyong, et al.
Publicado: (2018)

Molecular basis of signaling specificity between GIRK channels and GPCRs
por: Touhara, Kouki K, et al.
Publicado: (2018)

Molecular structure of human KATP in complex with ATP and ADP
por: Lee, Kenneth Pak Kin, et al.
Publicado: (2017)

Cryo-EM analysis of PIP(2) regulation in mammalian GIRK channels
por: Niu, Yiming, et al.
Publicado: (2020)

Analysis of the mechanosensor channel functionality of TACAN
por: Niu, Yiming, et al.
Publicado: (2021)

Structure-based membrane dome mechanism for Piezo mechanosensitivity
por: Guo, Yusong R, et al.
Publicado: (2017)

Slo1 is the principal potassium channel of human spermatozoa
por: Mannowetz, Nadja, et al.
Publicado: (2013)

Phosphatidic acid modulation of Kv channel voltage sensor function
por: Hite, Richard K, et al.
Publicado: (2014)

Piezo’s membrane footprint and its contribution to mechanosensitivity
por: Haselwandter, Christoph A, et al.
Publicado: (2018)

The Ca(2+)-activated K(+) current of human sperm is mediated by Slo3
por: Brenker, Christoph, et al.
Publicado: (2014)

Knockout of Slo2.2 enhances itch, abolishes K(Na) current, and increases action potential firing frequency in DRG neurons
por: Martinez-Espinosa, Pedro L, et al.
Publicado: (2015)

Cryo-EM structure of the Slo2.2 Na(+)-activated K(+) channel
por: Hite, Richard, et al.
Publicado: (2015)

The molecular basis for an allosteric inhibition of K(+)-flux gating in K(2P) channels
por: Rinné, Susanne, et al.
Publicado: (2019)

Structural basis for ion selectivity in TMEM175 K(+) channels
por: Brunner, Janine D, et al.
Publicado: (2020)

Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy
por: Andrecka, Joanna, et al.
Publicado: (2015)

Structure of a TRPM2 channel in complex with Ca(2+) explains unique gating regulation
por: Zhang, Zhe, et al.
Publicado: (2018)

Mechanism of activation at the selectivity filter of the KcsA K(+) channel
por: Heer, Florian T, et al.
Publicado: (2017)

Gating and selectivity mechanisms for the lysosomal K(+) channel TMEM175
por: Oh, SeCheol, et al.
Publicado: (2020)

Structural and functional characterization of an otopetrin family proton channel
por: Chen, Qingfeng, et al.
Publicado: (2019)

Activation of the archaeal ion channel MthK is exquisitely regulated by temperature
por: Jiang, Yihao, et al.
Publicado: (2020)

Structural mechanisms of phospholipid activation of the human TPC2 channel
por: She, Ji, et al.
Publicado: (2019)

Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics
por: Ananth, Adithya N, et al.
Publicado: (2018)

Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel
por: Kong, Chunguang, et al.
Publicado: (2012)

Electron cryo-microscopy structure of the canonical TRPC4 ion channel
por: Vinayagam, Deivanayagabarathy, et al.
Publicado: (2018)

Mechanism of pharmacochaperoning in a mammalian K(ATP) channel revealed by cryo-EM
por: Martin, Gregory M, et al.
Publicado: (2019)

Molecular mechanism of TRPV2 channel modulation by cannabidiol
por: Pumroy, Ruth A, et al.
Publicado: (2019)

Structure of the human volume regulated anion channel
por: Kefauver, Jennifer M, et al.
Publicado: (2018)

Activation mechanism of ATP-sensitive K(+) channels explored with real-time nucleotide binding
por: Puljung, Michael, et al.
Publicado: (2019)

Nucleotide inhibition of the pancreatic ATP-sensitive K(+) channel explored with patch-clamp fluorometry
por: Usher, Samuel G, et al.
Publicado: (2020)

Molecular determinants of permeation in a fluoride-specific ion channel
por: Last, Nicholas B, et al.
Publicado: (2017)

Molecular principles of assembly, activation, and inhibition in epithelial sodium channel
por: Noreng, Sigrid, et al.
Publicado: (2020)

Structural basis for pharmacological modulation of the TRPC6 channel
por: Bai, Yonghong, et al.
Publicado: (2020)

Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS
por: Reddy, Bharat, et al.
Publicado: (2019)

Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC
por: Osei-Owusu, James, et al.
Publicado: (2022)

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K(+) channel TMEM175
por: Oh, SeCheol, et al.
Publicado: (2022)

Molecular structures of the eukaryotic retinal importer ABCA4
por: Liu, Fangyu, et al.
Publicado: (2021)

Structure of the human lipid-gated cation channel TRPC3
por: Fan, Chen, et al.
Publicado: (2018)

Structure of the human epithelial sodium channel by cryo-electron microscopy
por: Noreng, Sigrid, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_j55lbkqhfd4gbspeuhnb2p06ct