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K(Ca)3.1 channel blockade attenuates microvascular remodelling in a large animal model of bleomycin-induced pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with limited therapeutic options and poor prognosis. IPF has been associated with aberrant vascular remodelling, however the role of vascular remodelling in pulmonary fibrosis is poorly understood. Here, we used a novel segmen...

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Detalles Bibliográficos
Autores principales: Derseh, Habtamu B., Dewage, Sasika N. Vithana, Perera, Kopiyawaththage U. E., Pagel, Charles N., Koumoundouros, Emmanuel, Organ, Louise, Snibson, Ken J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934539/
https://www.ncbi.nlm.nih.gov/pubmed/31882807
http://dx.doi.org/10.1038/s41598-019-56412-z