Phenoxyethyl Piperidine/Morpholine Derivatives as PAS and CAS Inhibitors of Cholinesterases: Insights for Future Drug Design

Acetylcholinesterase (AChE) catalyzes the conversion of Aβ peptide to its aggregated form and the peripheral anionic site (PAS) of AChE is mainly involved in this phenomenon. Also catalytic active site (CAS) of donepezil stimulates the break-down of acetylcholine (ACh) and depletion of ACh in cholin...

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Detalles Bibliográficos
Autores principales: Pourshojaei, Yaghoub, Abiri, Ardavan, Eskandari, Khalil, Haghighijoo, Zahra, Edraki, Najmeh, Asadipour, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934599/
https://www.ncbi.nlm.nih.gov/pubmed/31882733
http://dx.doi.org/10.1038/s41598-019-56463-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934599/
https://www.ncbi.nlm.nih.gov/pubmed/31882733
http://dx.doi.org/10.1038/s41598-019-56463-2

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