Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method

Generation of mutant imprinting control region (ICR) mice using genome editing is an important approach for elucidating ICR functions. IG-DMR is an ICR in the Dlk1-Dio3 imprinted domain that contains functional regions—in both parental alleles—that are essential for embryonic development. One drawba...

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Detalles Bibliográficos
Autores principales: Hara, Satoshi, Terao, Miho, Muramatsu, Akari, Takada, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934616/
https://www.ncbi.nlm.nih.gov/pubmed/31882978
http://dx.doi.org/10.1038/s41598-019-56676-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934616/
https://www.ncbi.nlm.nih.gov/pubmed/31882978
http://dx.doi.org/10.1038/s41598-019-56676-5

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