Small molecule allosteric uncoupling of microtubule depolymerase activity from motility in human Kinesin-5 during mitotic spindle assembly

Human Kinesin-5 (Eg5) has a large number of known allosteric inhibitors that disrupt its mitotic function. Small-molecule inhibitors of Eg5 are candidate anti-cancer agents and important probes for understanding the cellular function. Here we show that Eg5 is capable of more than one type of microtu...

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Detalles Bibliográficos
Autores principales: Kim, Catherine D., Kim, Elizabeth D., Liu, Liqiong, Buckley, Rebecca S., Parameswaran, Sreeja, Kim, Sunyoung, Wojcik, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934681/
https://www.ncbi.nlm.nih.gov/pubmed/31882607
http://dx.doi.org/10.1038/s41598-019-56173-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934681/
https://www.ncbi.nlm.nih.gov/pubmed/31882607
http://dx.doi.org/10.1038/s41598-019-56173-9

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