Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance

B cells are postulated to be central in seropositive rheumatoid arthritis (RA). Here, we use exploratory mass cytometry (n = 23) and next-generation sequencing (n = 19) to study B-cell repertoire shifts in RA patients. Expression of several B-cell markers were significantly different in ACPA(+) RA c...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Lloyd, Katy A., Melas, Ioannis, Zhou, Diana, Thyagarajan, Radha, Lindqvist, Joakim, Hansson, Monika, Svärd, Anna, Mathsson-Alm, Linda, Kastbom, Alf, Lundberg, Karin, Klareskog, Lars, Catrina, Anca I., Rapecki, Stephen, Malmström, Vivianne, Grönwall, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934703/
https://www.ncbi.nlm.nih.gov/pubmed/31882654
http://dx.doi.org/10.1038/s41598-019-56279-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934703/
https://www.ncbi.nlm.nih.gov/pubmed/31882654
http://dx.doi.org/10.1038/s41598-019-56279-0

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