Development of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering

The use of recombinant allergens is a promising approach in allergen-specific immunotherapy (AIT). Considerable limitation, however, has been the ability of recombinant allergens to activate effector cells leading to allergic reactions. Recombinant hypoallergens with preserved protein folding and ca...

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Detalles Bibliográficos
Autores principales: Haka, Jaana, Niemi, Merja H., Mattila, Pekka, Jänis, Janne, Takkinen, Kristiina, Rouvinen, Juha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934807/
https://www.ncbi.nlm.nih.gov/pubmed/31882906
http://dx.doi.org/10.1038/s41598-019-56812-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934807/
https://www.ncbi.nlm.nih.gov/pubmed/31882906
http://dx.doi.org/10.1038/s41598-019-56812-1

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