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Development of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering
The use of recombinant allergens is a promising approach in allergen-specific immunotherapy (AIT). Considerable limitation, however, has been the ability of recombinant allergens to activate effector cells leading to allergic reactions. Recombinant hypoallergens with preserved protein folding and ca...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934807/ https://www.ncbi.nlm.nih.gov/pubmed/31882906 http://dx.doi.org/10.1038/s41598-019-56812-1 |