A New Model to Describe the Single-dose Pharmacokinetics of Bevacizumab and Predict Its Multiple-Dose Pharmacokinetics in Beagle Dogs

Complex pharmacokinetic (PK) properties including nonlinear elimination were encountered by some monoclonal antibodies (mAbs), and classic compartment models sometimes failed to appropriately describe those properties. In this work, a new model was built on a comprehensive analysis of the complex el...

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Detalles Bibliográficos
Autores principales: Li, Meizhen, Qiang, Wei, Wen, Zhou, Li, Linling, Wang, Lei, Cheng, Zeneng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934983/
https://www.ncbi.nlm.nih.gov/pubmed/32641928
http://dx.doi.org/10.22037/ijpr.2019.1100716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934983/
https://www.ncbi.nlm.nih.gov/pubmed/32641928
http://dx.doi.org/10.22037/ijpr.2019.1100716

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