Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site

BACKGROUND: Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of polyubiquitinated proteins and other aggregates, are associated with neurodegenerative disease independently and through interactions of the two...

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Detalles Bibliográficos
Autores principales: Balasubramaniam, Meenakshisundaram, Parcon, Paul A., Bose, Chhanda, Liu, Ling, Jones, Richard A., Farlow, Martin R., Mrak, Robert E., Barger, Steven W., Griffin, W. Sue T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935243/
https://www.ncbi.nlm.nih.gov/pubmed/31882005
http://dx.doi.org/10.1186/s12974-019-1669-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935243/
https://www.ncbi.nlm.nih.gov/pubmed/31882005
http://dx.doi.org/10.1186/s12974-019-1669-z

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