Cargando…

Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons

BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with pronounced heritability in the general population. This is largely attributable to the effects of polygenic susceptibility, with inherited liability exhibiting distinct sex differences in phenotypic expression. Attempts...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lewis, Emily M. A., Meganathan, Kesavan, Baldridge, Dustin, Gontarz, Paul, Zhang, Bo, Bonni, Azad, Constantino, John N., Kroll, Kristen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936127/ https://www.ncbi.nlm.nih.gov/pubmed/31893020 http://dx.doi.org/10.1186/s13229-019-0306-0

Ejemplares similares

Complexities of X chromosome inactivation status in female human induced pluripotent stem cells—a brief review and scientific update for autism research
por: Dandulakis, Mary G., et al.
Publicado: (2016)

Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7
por: Meganathan, Kesavan, et al.
Publicado: (2021)

Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders
por: Anderson, Nickesha C., et al.
Publicado: (2021)

Regulation of Neuronal Morphogenesis and Positioning by Ubiquitin-Specific Proteases in the Cerebellum
por: Anckar, Julius, et al.
Publicado: (2015)

Reliable multiplex generation of pooled induced pluripotent stem cells
por: Smullen, Molly, et al.
Publicado: (2023)

Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells
por: Pfaender, Stefanie, et al.
Publicado: (2016)

Targeting OSMR in glioma stem cells
por: Mohan, Sushmetha, et al.
Publicado: (2017)

22q11.2 duplication: a review of neuropsychiatric correlates and a newly observed case of prototypic sociopathy
por: Vyas, Sonam, et al.
Publicado: (2019)

Modeling neuronal consequences of autism-associated gene regulatory variants with human induced pluripotent stem cells
por: Ross, P. Joel, et al.
Publicado: (2020)

Derivation of trophoblast stem cells from naïve human pluripotent stem cells
por: Dong, Chen, et al.
Publicado: (2020)

Regulation of human cortical interneuron development by the chromatin remodeling protein CHD2
por: Lewis, E. M. A., et al.
Publicado: (2022)

Capture of Neuroepithelial-Like Stem Cells from Pluripotent Stem Cells Provides a Versatile System for In Vitro Production of Human Neurons
por: Falk, Anna, et al.
Publicado: (2012)

APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation
por: Mertens, Jerome, et al.
Publicado: (2013)

Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells
por: Prytkova, Iya, et al.
Publicado: (2017)

Deletion of TRPC6, an Autism Risk Gene, Induces Hyperexcitability in Cortical Neurons Derived from Human Pluripotent Stem Cells
por: Shin, Kyung Chul, et al.
Publicado: (2023)

Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity
por: Sarrafha, Lily, et al.
Publicado: (2023)

Characterization of a Mouse Model of Börjeson-Forssman-Lehmann Syndrome
por: Cheng, Cheng, et al.
Publicado: (2018)

Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dish
por: Aigner, Stefan, et al.
Publicado: (2013)

Altered neurite morphology and cholinergic function of induced pluripotent stem cell-derived neurons from a patient with Kleefstra syndrome and autism
por: Nagy, J, et al.
Publicado: (2017)

A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development
por: Christensen, Ryan, et al.
Publicado: (2011)

Intrinsically Active and Pacemaker Neurons in Pluripotent Stem Cell-Derived Neuronal Populations
por: Illes, Sebastian, et al.
Publicado: (2014)

Specification of Region-Specific Neurons Including Forebrain Glutamatergic Neurons from Human Induced Pluripotent Stem Cells
por: Zeng, Hui, et al.
Publicado: (2010)

Destroy to create: E3 ubiquitin ligases in neurogenesis
por: Stegmüller, Judith, et al.
Publicado: (2010)

A decade of the anaphase-promoting complex in the nervous system
por: Huang, Ju, et al.
Publicado: (2016)

T9. EPIGENETIC PROFILING IN SCHIZOPHRENIA DERIVED HUMAN INDUCED PLURIPOTENT STEM CELLS (HIPSCS) AND NEURONS
por: Farrelly, Lorna, et al.
Publicado: (2020)

Neuronal-Specific Deficiency of the Splicing Factor Tra2b Causes Apoptosis in Neurogenic Areas of the Developing Mouse Brain
por: Storbeck, Markus, et al.
Publicado: (2014)

Uncovering True Cellular Phenotypes: Using Induced Pluripotent Stem Cell-Derived Neurons to Study Early Insults in Neurodevelopmental Disorders
por: Fink, James J., et al.
Publicado: (2018)

The Emerging Role of Induced Pluripotent Stem Cells as Adoptive Cellular Immunotherapeutics
por: Mehra, Vedika, et al.
Publicado: (2023)

Partial Reprogramming of Pluripotent Stem Cell-Derived Cardiomyocytes into Neurons
por: Chuang, Wenpo, et al.
Publicado: (2017)

Regulation of epithelial-mesenchymal transition and organoid morphogenesis by a novel TGFβ-TCF7L2 isoform-specific signaling pathway
por: Karve, Kunal, et al.
Publicado: (2020)

Sumoylated SnoN interacts with HDAC1 and p300/CBP to regulate EMT-associated phenotypes in mammary organoids
por: Chanda, Ayan, et al.
Publicado: (2023)

High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes
por: Grimm, Fabian Alexander, et al.
Publicado: (2015)

Multiplexing physical stimulation on single human induced pluripotent stem cell-derived cardiomyocytes for phenotype modulation
por: Kit-Anan, Worrapong, et al.
Publicado: (2021)

Using human pluripotent stem cell models to study autism in the era of big data
por: Nehme, Ralda, et al.
Publicado: (2020)

Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids
por: Santos, John Lenon de Souza, et al.
Publicado: (2023)

Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations
por: Kilpatrick, Savannah, et al.
Publicado: (2023)

Whole-genome sequencing in an autism multiplex family
por: Shi, Lingling, et al.
Publicado: (2013)

Neurons Derived From Patient-Specific Induced Pluripotent Stem Cells: a Promising Strategy Towards Developing Novel Pharmacotherapies for Autism Spectrum Disorders
por: Mokhtari, Ryan, et al.
Publicado: (2016)

The human-induced pluripotent stem cell initiative—data resources for cellular genetics
por: Streeter, Ian, et al.
Publicado: (2017)

Induced pluripotent stem cells as a cellular model for studying Down Syndrome
por: Brigida, Anna Lisa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_14hko0ruo38org5nnk6btt940d