Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington’s Disease

Multiple pathomechanisms triggered by mutant Huntingtin (mHTT) underlie progressive degeneration of dopaminoceptive striatal neurons in Huntington’s disease (HD). The primary cilium is a membrane compartment that functions as a hub for various pathways that are dysregulated in HD, for example, dopam...

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Detalles Bibliográficos
Autores principales: Mustafa, Rasem, Kreiner, Grzegorz, Kamińska, Katarzyna, Wood, Amelia-Elise J., Kirsch, Joachim, Tucker, Kerry L., Parlato, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936315/
https://www.ncbi.nlm.nih.gov/pubmed/31920562
http://dx.doi.org/10.3389/fncel.2019.00565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936315/
https://www.ncbi.nlm.nih.gov/pubmed/31920562
http://dx.doi.org/10.3389/fncel.2019.00565

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