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Affinity maturation in a human humoral response to influenza hemagglutinin

Affinity maturation of the B cell antigen receptor (BCR) is a conserved and crucial component of the adaptive immune response. BCR lineages, inferred from paired heavy- and light-chain sequences of rearranged Ig genes from multiple descendants of the same naive B cell precursor (the lineages’ unmuta...

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Detalles Bibliográficos
Autores principales: McCarthy, Kevin R., Raymond, Donald D., Do, Khoi T., Schmidt, Aaron G., Harrison, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936356/
https://www.ncbi.nlm.nih.gov/pubmed/31843892
http://dx.doi.org/10.1073/pnas.1915620116