IgGs from patients with amyotrophic lateral sclerosis and diabetes target Ca(V)α(2)δ1 subunits impairing islet cell function and survival

Patients with amyotrophic lateral sclerosis (ALS) often show hallmarks of type 2 diabetes mellitus (T2DM). However, the causal link between ALS and T2DM has remained a mystery. We now demonstrate that 60% of ALS patients with T2DM (ALS-T2DM) have sera that exaggerated K(+)-induced increases in cytos...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Yue, Park, Kyoung Sun, Kim, Seung Hyun, Yu, Jia, Zhao, Kaixuan, Yu, Lina, Oh, Ki Wook, Lee, Kayoung, Kim, Jaeyoon, Chaggar, Kanchan, Li, Yuxin, Dolphin, Annette C., Catterall, William A., Ryu, Sung Ho, Yang, Shao-Nian, Berggren, Per-Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936400/
https://www.ncbi.nlm.nih.gov/pubmed/31826954
http://dx.doi.org/10.1073/pnas.1911956116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936400/
https://www.ncbi.nlm.nih.gov/pubmed/31826954
http://dx.doi.org/10.1073/pnas.1911956116

Ejemplares similares