A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

Adeno-associated virus (AAV) capsid modification enables the generation of recombinant vectors with tailored properties and tropism. Most approaches to date depend on random screening, enrichment, and serendipity. The approach explored here, called BRAVE (barcoded rational AAV vector evolution), ena...

Descripción completa

Detalles Bibliográficos
Autores principales: Davidsson, Marcus, Wang, Gang, Aldrin-Kirk, Patrick, Cardoso, Tiago, Nolbrant, Sara, Hartnor, Morgan, Mudannayake, Janitha, Parmar, Malin, Björklund, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936499/
https://www.ncbi.nlm.nih.gov/pubmed/31818949
http://dx.doi.org/10.1073/pnas.1910061116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936499/
https://www.ncbi.nlm.nih.gov/pubmed/31818949
http://dx.doi.org/10.1073/pnas.1910061116

Ejemplares similares