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A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism
Adeno-associated virus (AAV) capsid modification enables the generation of recombinant vectors with tailored properties and tropism. Most approaches to date depend on random screening, enrichment, and serendipity. The approach explored here, called BRAVE (barcoded rational AAV vector evolution), ena...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936499/ https://www.ncbi.nlm.nih.gov/pubmed/31818949 http://dx.doi.org/10.1073/pnas.1910061116 |