Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development

In mammals, T cell development critically depends on the IL-7 cytokine signaling pathway. Here we describe the identification of the zebrafish ortholog of mammalian IL-7 based on chromosomal localization, deduced protein sequence, and expression patterns. To examine the biological role of il7 in tel...

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Detalles Bibliográficos
Autores principales: Lawir, Divine-Fondzenyuy, Hess, Isabell, Sikora, Katarzyna, Iwanami, Norimasa, Siamishi, Iliana, Schorpp, Michael, Boehm, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936713/
https://www.ncbi.nlm.nih.gov/pubmed/31822609
http://dx.doi.org/10.1073/pnas.1915223116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936713/
https://www.ncbi.nlm.nih.gov/pubmed/31822609
http://dx.doi.org/10.1073/pnas.1915223116

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