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Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development
In mammals, T cell development critically depends on the IL-7 cytokine signaling pathway. Here we describe the identification of the zebrafish ortholog of mammalian IL-7 based on chromosomal localization, deduced protein sequence, and expression patterns. To examine the biological role of il7 in tel...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936713/ https://www.ncbi.nlm.nih.gov/pubmed/31822609 http://dx.doi.org/10.1073/pnas.1915223116 |