IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody

Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human primates and their efficacy may be enhanced through interaction with Fc receptors on immune cells. Antibody isotype is a modulator of this binding with the IgG3 subclass mediating potent Fc effector function and is as...

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Detalles Bibliográficos
Autores principales: Richardson, Simone I., Lambson, Bronwen E., Crowley, Andrew R., Bashirova, Arman, Scheepers, Cathrine, Garrett, Nigel, Abdool Karim, Salim, Mkhize, Nonhlanhla N., Carrington, Mary, Ackerman, Margaret E., Moore, Penny L., Morris, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936867/
https://www.ncbi.nlm.nih.gov/pubmed/31841557
http://dx.doi.org/10.1371/journal.ppat.1008064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936867/
https://www.ncbi.nlm.nih.gov/pubmed/31841557
http://dx.doi.org/10.1371/journal.ppat.1008064

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