ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C

Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its recruitment to the surface of lysosomes via the Rag guanosine triphosphatases (GTPases). The mechanisms that regulate lysosomal cholesterol content to enable mTORC1 signaling are unknown. We show that Oxysterol Bindin...

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Detalles Bibliográficos
Autores principales: Lim, Chun-Yan, Davis, Oliver B., Shin, Hijai R., Zhang, Justin, Berdan, Charles A., Jiang, Xuntian, Counihan, Jessica L., Ory, Daniel S., Nomura, Daniel K., Zoncu, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936960/
https://www.ncbi.nlm.nih.gov/pubmed/31548609
http://dx.doi.org/10.1038/s41556-019-0391-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936960/
https://www.ncbi.nlm.nih.gov/pubmed/31548609
http://dx.doi.org/10.1038/s41556-019-0391-5

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