Characterization and engineering of broadly reactive monoclonal antibody against hepatitis B virus X protein that blocks its interaction with DDB1

Hepatitis B virus (HBV) X protein (HBx) plays diverse roles in both viral life cycle and HBV-related carcinogenesis. Its interaction with DNA damage-binding protein 1 (DDB1) was shown to be essential for engendering cellular conditions favorable for optimal viral transcription and replication. Previ...

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Detalles Bibliográficos
Autores principales: Tao, Shuai, Pan, Shaokun, Gu, Chenjian, Wei, Lili, Kang, Ning, Xie, Youhua, Liu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937242/
https://www.ncbi.nlm.nih.gov/pubmed/31889135
http://dx.doi.org/10.1038/s41598-019-56819-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937242/
https://www.ncbi.nlm.nih.gov/pubmed/31889135
http://dx.doi.org/10.1038/s41598-019-56819-8

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