Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site

Mycobacterium tuberculosis is the cause of the world’s most deadly infectious disease. Efforts are underway to target the methionine biosynthesis pathway, as it is not part of the host metabolism. The homoserine transacetylase MetX converts l-homoserine to O-acetyl-l-homoserine at the committed step...

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Detalles Bibliográficos
Autores principales: Chaton, Catherine T., Rodriguez, Emily S., Reed, Robert W., Li, Jian, Kenner, Cameron W., Korotkov, Konstantin V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937278/
https://www.ncbi.nlm.nih.gov/pubmed/31889085
http://dx.doi.org/10.1038/s41598-019-56722-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937278/
https://www.ncbi.nlm.nih.gov/pubmed/31889085
http://dx.doi.org/10.1038/s41598-019-56722-2

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