Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas

Osteosarcoma (OS) patients with metastasis or recurrent tumors still suffer from poor prognosis. Studies have indicated the efficacy of DNA demethylation therapy for OS, but the underlying mechanism is still unclear. Here, we aimed to clarify the mechanism of how epigenetic therapy has therapeutic e...

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Detalles Bibliográficos
Autores principales: Asano, Naofumi, Takeshima, Hideyuki, Yamashita, Satoshi, Takamatsu, Hironori, Hattori, Naoko, Kubo, Takashi, Yoshida, Akihiko, Kobayashi, Eisuke, Nakayama, Robert, Matsumoto, Morio, Nakamura, Masaya, Ichikawa, Hitoshi, Kawai, Akira, Kondo, Tadashi, Ushijima, Toshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937291/
https://www.ncbi.nlm.nih.gov/pubmed/31889115
http://dx.doi.org/10.1038/s41598-019-56883-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937291/
https://www.ncbi.nlm.nih.gov/pubmed/31889115
http://dx.doi.org/10.1038/s41598-019-56883-0

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